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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2559
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:2682
Term: amphotericin B
Definition: A macrolide antibiotic used to treat potentially life-threatening fungal infections.
Chemical ID: MESH:D000666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epomultiple interactionsEXP 6480464CTDAmphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]PMID:16189267
Epodecreases expressionISOEPO (Homo sapiens)6480464CTDAmphotericin B results in decreased expression of EPO proteinPMID:2299214 PMID:697352
Epomultiple interactionsISOEPO (Homo sapiens)6480464CTDAmphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]PMID:16189267
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