Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:2672
Term: Ammothamnine
Definition: An alkaloid that has formula C15H24N2O2.
Chemical ID: MESH:C037573
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTDoxymatrine promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]PMID:27713174
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[oxymatrine co-treated with IL1B protein] results in decreased expression of NFE2L2 protein; [oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased stability of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [oxymatrine inhibits the reaction [IL1B protein results in increased expression of RELA protein]]; NFE2L2 protein promotes the reaction [oxymatrine promotes the reaction [IL1B protein results in increased expression of HMOX1 protein]]; oxymatrine inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; oxymatrine promotes the reaction [IL1B protein results in increased expression of NFE2L2 protein]PMID:37196756
Go Back to source page   Continue to Ontology report