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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdk2 Name: cyclin dependent kinase 2

Acc ID: CHEBI:2668 Term: amlodipine Definition: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina. CasRN: 88150-42-9 Chemical ID: MESH:D017311

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	ISO	RGD:1352010	6480464	CTD	Amlodipine results in decreased activity of CDK2 protein	PMID:17217918