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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3903 Species: Rattus norvegicus RGD Object: Gene Symbol: Trh Name: thyrotropin releasing hormone

Acc ID: CHEBI:2666 Term: amitriptyline Definition: A tricyclic antidepressant that has formula C20H23N. CasRN: 50-48-6 Chemical ID: MESH:D000639

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:69154	6480464	CTD	Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein]	PMID:6455462