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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tg
Name: thyroglobulin
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgincreases expressionEXP 6480464CTDAmiodarone results in increased expression of TG mRNAPMID:27197836
Tgdecreases expressionISOTG (Homo sapiens)6480464CTDAmiodarone results in decreased expression of TG mRNA; Amiodarone results in decreased expression of TG proteinPMID:18020914 PMID:25295624
Tgmultiple interactionsISOTG (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Amiodarone results in decreased expression of TG protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Amiodarone results in decreased expression of TG protein]PMID:25295624
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