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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308166
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c79
Name: cytochrome P450, family 2, subfamily c, polypeptide 79
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c79decreases activityISOCYP2C8 (Homo sapiens)6480464CTDAmiodarone results in decreased activity of CYP2C8 proteinPMID:15304522
Cyp2c79decreases response to substanceISOCYP2C8 (Homo sapiens)6480464CTDCYP2C8 protein results in decreased susceptibility to AmiodaronePMID:26477383
Cyp2c79increases metabolic processingISOCYP2C8 (Homo sapiens)6480464CTDCYP2C8 protein results in increased metabolism of AmiodaronePMID:15716363
Cyp2c79multiple interactionsISOCYP2C8 (Homo sapiens)6480464CTDtorsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]PMID:15304522
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