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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620573
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyba
Name: cytochrome b-245 alpha chain
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cybamultiple interactionsEXP 6480464CTD[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein; [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species; [[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species; CYBA protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species]; resveratrol inhibits the reaction [[[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression of NCF1 protein]] results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of FN1 protein]PMID:21562509 PMID:22245600
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