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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases abundanceISOVEGFA (Homo sapiens)6480464CTDVEGFA protein results in increased abundance of Reactive Oxygen SpeciesPMID:12855698
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA; [Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of VEGFA mRNA; [cobaltous chloride results in increased chemical synthesis of Reactive Oxygen Species] which results in increased expression of VEGFA mRNA; [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of VEGFA mRNA; CAT protein inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; PAK1 protein promotes the reaction [VEGFA protein results in increased abundance of Reactive Oxygen Species]PMID:12855698 PMID:13679210 PMID:21687637 PMID:24489904
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