GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | [[[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein] promotes the reaction [STAT3 protein binds to STAT3 protein]; [[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in increased phosphorylation of STAT3 protein] which results in increased expression of MT2; [[[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] which results in increased activity of SRC protein] which results in increased activity of EGFR protein] which results in increased activity of STAT3 protein; [[Cadmium Chloride results in increased abundance of Reactive Oxygen Species] results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]] which results in increased phosphorylation of STAT3 protein | PMID:23376140 | | ||||||||||||||||||||||
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