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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2increases phosphorylationISOPTK2 (Homo sapiens)6480464CTDReactive Oxygen Species results in increased phosphorylation of PTK2 proteinPMID:11213483
Ptk2multiple interactionsISOPTK2 (Homo sapiens)6480464CTD[[Thimerosal results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP3 protein] which results in increased cleavage of PTK2 protein; Acetylcysteine inhibits the reaction [[[Thimerosal results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP3 protein] which results in increased cleavage of PTK2 protein]; Anethole Trithione inhibits the reaction [Reactive Oxygen Species results in increased phosphorylation of PTK2 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[[Thimerosal results in increased abundance of Reactive Oxygen Species] which results in increased activity of CASP3 protein] which results in increased cleavage of PTK2 protein]PMID:11213483 PMID:17888894
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