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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2532
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Edn1
Name: endothelin 1
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Edn1increases abundanceEXP 6480464CTDEDN1 protein results in increased abundance of Reactive Oxygen SpeciesPMID:16391241 PMID:22431579
Edn1increases chemical synthesisEXP 6480464CTDEDN1 protein results in increased chemical synthesis of Reactive Oxygen SpeciesPMID:16271043
Edn1multiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]; atrasentan inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]; BQ 485 inhibits the reaction [EDN1 protein results in increased abundance of Reactive Oxygen Species]PMID:16391241 PMID:22431579
Edn1increases expressionISOEDN1 (Homo sapiens)6480464CTDReactive Oxygen Species results in increased expression of EDN1 proteinPMID:11603923
Edn1multiple interactionsISOEDN1 (Homo sapiens)6480464CTDReactive Oxygen Species results in increased phosphorylation of and results in increased activity of EDN1 proteinPMID:11603923
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