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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61296
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aoc1
Name: amine oxidase, copper containing 1
Acc ID: CHEBI:2639
Term: amiloride
Definition: A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.
Chemical ID: MESH:D000584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aoc1affects bindingEXP 724757RGDAmiloride binds to Aoc1 protein 
Aoc1multiple interactionsEXP 724757RGDAmiloride inhibits the reaction [Phenylamil binds to Aoc1 protein] 
Aoc1affects bindingISOAOC1 (Homo sapiens)6480464CTDAmiloride binds to AOC1 proteinPMID:2217167
Aoc1decreases activityISOAOC1 (Homo sapiens)6480464CTDAmiloride results in decreased activity of AOC1 proteinPMID:8144586
Aoc1multiple interactionsISOAOC1 (Homo sapiens)6480464CTDAmiloride inhibits the reaction [AOC1 protein results in increased degradation of Putrescine]PMID:8144586
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