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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:25942
Term: peroxynitrous acid
Definition: A nitrogen oxoacid that has formula HNO3.
Chemical ID: MESH:D030421
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5decreases activityEXP 6480464CTDPeroxynitrous Acid results in decreased activity of ALOX5 proteinPMID:12388339
Alox5multiple interactionsEXP 6480464CTDPeroxynitrous Acid results in increased nitrosation of and affects the expression of ALOX5 protein; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]PMID:11561080
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