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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806 Species: Rattus norvegicus RGD Object: Gene Symbol: Hmox1 Name: heme oxygenase (decycling) 1

Acc ID: CHEBI:25879 Term: pentaerythritol tetranitrate Definition: A pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to those of glyceryl trinitrate, but with a more prolonged duration of action, and is used for treatment of angina pectoris. It is also one of the most powerful high explosives known and is a component of the plastic explosive known as Semtex. CasRN: 78-11-5 Chemical ID: MESH:D010417

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:730901	6480464	CTD	Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA	PMID:17641250
increases activity	EXP		6480464	CTD	Pentaerythritol Tetranitrate results in increased activity of HMOX1 protein	PMID:17541025
increases expression	ISO	RGD:10717	6480464	CTD	Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA	PMID:17092343
increases expression	EXP		6480464	CTD	Pentaerythritol Tetranitrate results in increased expression of HMOX1 protein Pentaerythritol Tetranitrate results in increased expression of HMOX1 mRNA	PMID:17541025