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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735430 Species: Homo sapiens RGD Object: Gene Symbol: IL1R1 Name: interleukin 1 receptor, type I

Acc ID: CHEBI:25812 Term: ozone Definition: A triatomic oxygen that has formula O3. CasRN: 10028-15-6 Chemical ID: MESH:D010126

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735431	6480464	CTD	IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of CCL11 protein] IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of IL6 protein] IL1R1 gene mutant form affects the reaction [Ozone results in increased expression of CXCL2 protein] IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1A protein] IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL10 protein] IL1R1 gene mutant form inhibits the reaction [Ozone results in increased expression of IL6 mRNA]	PMID:17575079
increases response to substance	ISO	RGD:735431	6480464	CTD	IL1R1 protein results in increased susceptibility to Ozone	PMID:17575079