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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1affects expressionEXP 6480464CTDOzone affects the expression of TGFB1 mRNAPMID:35112007
Tgfb1multiple interactionsEXP 6480464CTD[Ozone co-treated with Nitrogen Dioxide] results in increased expression of TGFB1 mRNAPMID:10986008
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDOzone results in increased expression of TGFB1 mRNAPMID:9820643
Tgfb1increases expressionISOTgfb1 (Mus musculus)6480464CTDOzone results in increased expression of TGFB1 proteinPMID:28279894
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TGFB1 protein; CTNNAL1 protein inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of TGFB1 protein]PMID:29791759
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDBudesonide inhibits the reaction [Ozone results in increased expression of TGFB1 protein]; Progesterone inhibits the reaction [Ozone results in increased expression of TGFB1 protein]PMID:28279894
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