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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621238
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1b
Name: TNF receptor superfamily member 1B
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1baffects expressionISOTnfrsf1b (Mus musculus)6480464CTDOzone affects the expression of TNFRSF1B mRNAPMID:11159038
Tnfrsf1bincreases expressionISOTNFRSF1B (Homo sapiens)6480464CTDOzone results in increased expression of TNFRSF1B mRNAPMID:31476115
Tnfrsf1bincreases expressionISOTnfrsf1b (Mus musculus)6480464CTDOzone results in increased expression of TNFRSF1B proteinPMID:15516495 PMID:16002559
Tnfrsf1bmultiple interactionsISOTNFRSF1B (Homo sapiens)6480464CTD[Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF1B mRNAPMID:31476115
Tnfrsf1bmultiple interactionsISOTnfrsf1b (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of TNFRSF1B mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of TNFRSF1B mRNA; [TNFRSF1B co-treated with CPE] promotes the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of IL23A mRNA]; IL6 gene mutant form inhibits the reaction [Ozone results in increased expression of TNFRSF1B protein]; TNFRSF1A protein affects the reaction [Ozone affects the expression of TNFRSF1B mRNA]; TNFRSF1B affects the reaction [[CPE affects the susceptibility to Ozone] which affects the expression of IL5 mRNA]; TNFRSF1B affects the reaction [CPE affects the susceptibility to Ozone]; TNFRSF1B affects the reaction [Ozone results in increased expression of CCL20 protein]; TNFRSF1B promotes the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of CCL20 mRNA]; TNFRSF1B promotes the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of CSF3 protein]; TNFRSF1B promotes the reaction [[Air Pollutants results in increased abundance of Ozone] which results in increased expression of IL17A mRNA]; TNFRSF1B protein affects the reaction [Ozone affects the expression of TNFRSF1A mRNA]PMID:11159038 PMID:15516495 PMID:23434795 PMID:24823369 PMID:34911549
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