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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1increases expressionEXP 6480464CTDOzone results in increased expression of SPP1; Ozone results in increased expression of SPP1 mRNAPMID:16716893 PMID:24103449
Spp1increases expressionISOSpp1 (Mus musculus)6480464CTDOzone results in increased expression of SPP1 mRNAPMID:12763052 PMID:25658374 PMID:33026818 PMID:35928613
Spp1increases expressionISOSPP1 (Homo sapiens)6480464CTDOzone results in increased expression of SPP1 mRNAPMID:31476115
Spp1multiple interactionsISOSpp1 (Mus musculus)6480464CTD3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide inhibits the reaction [Ozone results in increased expression of SPP1 mRNA]; [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of SPP1 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in increased expression of SPP1 mRNA; TTPA protein affects the reaction [Ozone results in increased expression of SPP1 mRNA]PMID:19555225 PMID:27106289 PMID:34911549 PMID:35928613
Spp1multiple interactionsISOSPP1 (Homo sapiens)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SPP1 mRNAPMID:26035830
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