GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Notch4 | decreases response to substance | ISO | Notch4 (Mus musculus) | 6480464 | CTD | NOTCH4 protein results in decreased susceptibility to Ozone | PMID:25658374 | Notch4 | multiple interactions | ISO | Notch4 (Mus musculus) | 6480464 | CTD | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of NOTCH4 mRNA; [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of NOTCH4 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of ATP6V0D2 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of AVPR1A mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of BCL2L15 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of CCL17 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of CCL7 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of CD200R4 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of CXCL3 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of DDC mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of DEPDC1A mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of ECM2 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of EREG mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of HAS2 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of HPX mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of LILRB4 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of LILRB4B mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of MFSD2 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of SERPINA3M mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of SLC26A4 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of SOCS3 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of SPC25 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of TEF mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of TFPI2 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of THBS3 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of TRIP13 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which results in decreased expression of LRG1 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which results in decreased expression of MT2 mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which results in increased expression of CLEC3B mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which results in increased expression of RELA mRNA; [NOTCH4 gene mutant form affects the susceptibility to Ozone] which results in increased expression of TNF mRNA; NOTCH4 gene mutant form promotes the reaction [Ozone results in increased expression of CXCL2 mRNA] | PMID:25658374 PMID:34911549 | | ||||||||||||||||||||||
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