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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2060
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb2
Name: adrenoceptor beta 2
Acc ID: CHEBI:2549
Term: albuterol
Definition: A member of the class of phenylethanolamines that is 4-(2-amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol having a tert-butyl group attached to the nirogen atom. It acts as a beta-adrenergic agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Chemical ID: MESH:D000420
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb2increases activityEXP 6480464CTDAlbuterol results in increased activity of ADRB2 proteinPMID:19363516
Adrb2multiple interactionsEXP 6480464CTD[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Hydroxyindoleacetic Acid; Albuterol binds to and results in increased activity of ADRB2 proteinPMID:15467267 PMID:2463453
Adrb2decreases expressionISOADRB2 (Homo sapiens)6480464CTDAlbuterol results in decreased expression of ADRB2 proteinPMID:16980553
Adrb2decreases response to substanceISOADRB2 (Homo sapiens)6480464CTDADRB2 gene polymorphism results in decreased susceptibility to AlbuterolPMID:15687340
Adrb2increases activityISOADRB2 (Homo sapiens)6480464CTDAlbuterol results in increased activity of ADRB2 proteinPMID:34601065
Adrb2increases phosphorylationISOADRB2 (Homo sapiens)6480464CTDAlbuterol results in increased phosphorylation of ADRB2 proteinPMID:14722251 PMID:16980553
Adrb2multiple interactionsISOAdrb2 (Mus musculus)6480464CTDAlbuterol binds to and results in increased activity of ADRB2 proteinPMID:19120125
Adrb2multiple interactionsISOADRB2 (Homo sapiens)6480464CTD[Albuterol binds to and results in increased activity of ADRB2 protein] which results in decreased abundance of Potassium; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Albuterol binds to and results in increased activity of ADRB2 protein; Albuterol inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Atenolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]; ICI 118551 inhibits the reaction [Albuterol results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Albuterol binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Albuterol binds to and results in increased activity of ADRB2 protein]PMID:10516654 PMID:10952688 PMID:12920204 PMID:14730417 PMID:16980553 PMID:34601065 PMID:8102213 PMID:8937731
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