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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axdecreases expressionISOH2AX (Homo sapiens)6480464CTDMustard Gas results in decreased expression of H2AX mRNAPMID:33491125
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDMustard Gas results in increased expression of H2AX protein modified formPMID:25102026
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDMustard Gas results in increased phosphorylation of H2AX proteinPMID:20435105 PMID:25448276
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDpifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein]PMID:25448276
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