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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359664
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt1
Name: keratin 1
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krt1increases cleavageISOKRT1 (Homo sapiens)6480464CTDMustard Gas results in increased cleavage of KRT1 proteinPMID:12482751
Krt1increases expressionISOKRT1 (Homo sapiens)6480464CTDMustard Gas results in increased expression of KRT1 mRNA; Mustard Gas results in increased expression of KRT1 proteinPMID:11428642 PMID:21524694 PMID:9665388
Krt1increases expressionISOKrt1 (Mus musculus)6480464CTDMustard Gas results in increased expression of KRT1 mRNAPMID:21939433
Krt1multiple interactionsISOKRT1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of KRT1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Mustard Gas results in increased expression of KRT1 protein]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 mRNA]; SB 203580 inhibits the reaction [Mustard Gas results in increased expression of KRT1 protein]PMID:21524694
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