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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118 Species: Homo sapiens RGD Object: Gene Symbol: PARP1 Name: poly (ADP-ribose) polymerase 1

Acc ID: CHEBI:25434 Term: bis(2-chloroethyl) sulfide Definition: An ethyl sulfide that has formula C4H8Cl2S. CasRN: 505-60-2 Chemical ID: MESH:D009151

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mustard Gas results in increased cleavage of PARP1 protein] FADD protein affects the reaction [Mustard Gas results in increased cleavage of PARP1 protein] Mustard Gas promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]	PMID:12482751
multiple interactions	EXP		6480464	CTD	CALM1 protein promotes the reaction [Mustard Gas results in increased cleavage of and results in increased activity of PARP1 protein]	PMID:16935404
increases cleavage	EXP		6480464	CTD	Mustard Gas results in increased cleavage of PARP1 protein	PMID:11886524 PMID:17229443 PMID:12482751
multiple interactions	EXP		6480464	CTD	PARP1 protein affects the reaction [Mustard Gas affects the activity of CASP3 protein]	PMID:11886524
multiple interactions	ISO	RGD:1551988	6480464	CTD	PARP1 protein inhibits the reaction [Mustard Gas results in increased activity of CASP3 protein]	PMID:11886524
increases cleavage	EXP		6480464	CTD	Mustard Gas results in increased cleavage of PARP1 protein	PMID:12482751 PMID:11886524 PMID:17229443
increases cleavage	EXP		6480464	CTD	Mustard Gas results in increased cleavage of PARP1 protein	PMID:17229443 PMID:12482751 PMID:11886524
increases cleavage	EXP		6480464	CTD	Mustard Gas results in increased cleavage of PARP1 protein	PMID:12482751 PMID:17229443 PMID:11886524
multiple interactions	EXP		6480464	CTD	BRCA2 protein inhibits the reaction [Mustard Gas results in increased cleavage of PARP1 protein]	PMID:20435105
increases cleavage	EXP		6480464	CTD	Mustard Gas results in increased cleavage of PARP1 protein	PMID:11886524 PMID:12482751 PMID:17229443 PMID:20435105
increases cleavage	ISO	RGD:2053	6480464	CTD	Mustard Gas results in increased cleavage of PARP1 protein	PMID:20659490