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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731748 Species: Homo sapiens RGD Object: Gene Symbol: JAK2 Name: Janus kinase 2

Acc ID: CHEBI:25351 Term: mevalonic acid Definition: A dihydroxy monocarboxylic acid comprising valeric acid having two hydroxy groups at the 3- and 5-positions together with a methyl group at the 3-position. CasRN: 150-97-0 Chemical ID: MESH:D008798

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2939	6480464	CTD	Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of JAK2 protein]]	PMID:16534557