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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731579 Species: Homo sapiens RGD Object: Gene Symbol: HMGCR Name: 3-hydroxy-3-methylglutaryl-CoA reductase

Acc ID: CHEBI:2504 Term: aflatoxin B1 Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11. CasRN: 1162-65-8 Chemical ID: MESH:D016604

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:731580	6480464	CTD	Aflatoxin B1 results in decreased expression of HMGCR mRNA	PMID:19770486
decreases expression	EXP		6480464	CTD	Aflatoxin B1 results in decreased expression of HMGCR mRNA	PMID:21641981