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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9decreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of CYP3A9 mRNAPMID:33354967
Cyp3a9affects expressionISOCYP3A5 (Homo sapiens)6480464CTDAflatoxin B1 affects the expression of CYP3A5 proteinPMID:20106945
Cyp3a9decreases expressionISOCYP3A5 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of CYP3A5 mRNAPMID:22100608 PMID:27153756 PMID:32234424
Cyp3a9increases activityISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 protein results in increased activity of Aflatoxin B1PMID:15454734
Cyp3a9increases expressionISOCYP3A5 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of CYP3A5 mRNAPMID:21632981 PMID:21994236
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