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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2d4decreases expressionISOCyp2d22 (Mus musculus)6480464CTDAflatoxin B1 results in decreased expression of CYP2D22 mRNAPMID:19770486
Cyp2d4increases methylationISOCYP2D6 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of CYP2D6 genePMID:27153756
Cyp2d4multiple interactionsISOCYP2D6 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1PMID:23397584
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