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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh1a1
Name: aldehyde dehydrogenase 1 family, member A1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh1a1increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of ALDH1A1 mRNAPMID:14600272 PMID:21813463 PMID:22484513 PMID:23052194 PMID:23385219 PMID:23630614 PMID:25378103 PMID:33354967
Aldh1a1decreases methylationISOALDH1A1 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of ALDH1A1 genePMID:27153756
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