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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:24527
Term: herbicide
Definition: A substance used to destroy plant pests.
Chemical ID: MESH:D006540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1increases expressionEXP 6480464CTDHerbicides results in increased expression of CYP19A1 mRNA; Herbicides results in increased expression of CYP19A1 proteinPMID:24930125
Cyp19a1multiple interactionsEXP 6480464CTD[perfluoro-n-nonanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of CYP19A1 mRNAPMID:25588985
Cyp19a1affects bindingISOCYP19A1 (Homo sapiens)6480464CTDHerbicides binds to CYP19A1 proteinPMID:15929894
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDHerbicides results in decreased activity of CYP19A1 proteinPMID:15929894 PMID:17486286
Cyp19a1decreases expressionISOCYP19A1 (Homo sapiens)6480464CTDHerbicides results in decreased expression of CYP19A1 mRNAPMID:15929894
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD[Glyphosate co-treated with Herbicides] affects the activity of CYP19A1 protein; [Glyphosate co-treated with Herbicides] affects the expression of CYP19A1 mRNAPMID:19539684
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