GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | increases expression | EXP | | 6480464 | CTD | Cadmium results in increased expression of PPARG mRNA | PMID:25388156 | Pparg | decreases expression | ISO | Pparg (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of PPARG protein | PMID:21848503 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARG protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PPARG mRNA; MitoTEMPO inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARG protein]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which affects the localization of RELA protein]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARG1 mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PDGFB mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of TGFB1 mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased phosphorylation of STAT6 protein]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HIF1A protein]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NOS2 mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of and affects the localization of STAT1 protein] | PMID:32917723 PMID:35301059 PMID:36602393 | Pparg | multiple interactions | ISO | Pparg (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PPARG mRNA | PMID:36200916 | | ||||||||||||||||||||||
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