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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldha
Name: lactate dehydrogenase A
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhamultiple interactionsEXP 6480464CTD[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of LDHA protein; puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of LDHA protein]PMID:33404196
Ldhadecreases expressionISOLDHA (Homo sapiens)6480464CTDCadmium results in decreased expression of LDHA mRNAPMID:21694771
Ldhamultiple interactionsISOLdha (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA proteinPMID:32917723 PMID:34481905
Ldhamultiple interactionsISOLDHA (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein; AZD3965 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; Cadmium inhibits the reaction [Oxygen deficiency results in increased expression of LDHA mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; HMGA2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; Sirolimus inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]PMID:10866824 PMID:33040242 PMID:34481905 PMID:36336208
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