GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of SIRT1 protein | PMID:37949422 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | [cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SIRT1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein; agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein]; bergenin inhibits the reaction [Cadmium results in decreased expression of SIRT1 protein]; puerarin inhibits the reaction [[cadmium acetate results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein]; SRT1720 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SIRT1 protein] | PMID:33404196 PMID:34558789 PMID:36356678 PMID:36527706 PMID:37949422 | Sirt1 | multiple interactions | ISO | SIRT1 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]; Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]] | PMID:25159133 | Sirt1 | multiple interactions | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIRT1 protein; Polystyrenes promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SIRT1 protein] | PMID:37022104 | |
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