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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711 Species: Homo sapiens RGD Object: Gene Symbol: CYP1A2 Name: cytochrome P450, family 1, subfamily A, polypeptide 2

Acc ID: CHEBI:223316 Term: (+)-artemisinin Definition: A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. CasRN: 63968-64-9 Chemical ID: MESH:C031327

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:10438	6480464	CTD	artemisinine results in increased expression of CYP1A2 mRNA	PMID:17962186
decreases activity	EXP		6480464	CTD	artemisinine results in decreased activity of CYP1A2 protein	PMID:11124226
increases expression	ISO	RGD:2459	6480464	CTD	artemisinine results in increased expression of CYP1A2 mRNA	PMID:16919048