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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:205919
Term: clobetasol
Definition: A 3-oxo-Delta(1),Delta(4)-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha positions, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis.
Chemical ID: MESH:D002990
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDClobetasol results in increased activity of NR1I2 proteinPMID:25455453
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[Clobetasol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNAPMID:25455453
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