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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:18917
Term: 1,3-dichloropropan-2-ol
Definition: A secondary alcohol that is isopropanol in which one hydrogen of each methyl group is substituted by a chlorine. A liquid at room temperature (melting point -4degreeC, boiling point 174degreeC at 760 mm Hg), it is used as a solvent for hard resins and nitrocellulose.
Chemical ID: MESH:C033489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTD1,3-dichloro-2-propanol results in increased expression of HMOX1 mRNAPMID:26143167
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTD1,3-dichloro-2-propanol results in decreased expression of HMOX1 proteinPMID:35870111
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTD1,3-dichloro-2-propanol results in decreased expression of HMOX1 proteinPMID:35870111
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Thiazoles binds to indoline] promotes the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]PMID:35870111
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