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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases expressionISOMmp9 (Mus musculus)6480464CTDNicotine results in decreased expression of MMP9 proteinPMID:20448088
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDNicotine results in increased expression of MMP9 mRNA; Nicotine results in increased expression of MMP9 proteinPMID:14569062 PMID:20061081
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTDMK-886 inhibits the reaction [Nicotine results in increased expression of MMP9 mRNA]PMID:20061081
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