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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionEXP 6480464CTDNicotine results in decreased expression of MMP2 mRNAPMID:34153408
Mmp2decreases expressionISOMmp2 (Mus musculus)6480464CTDNicotine results in decreased expression of MMP2 proteinPMID:20448088
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDNicotine results in increased expression of MMP2 mRNA; Nicotine results in increased expression of MMP2 proteinPMID:14569062 PMID:17151781 PMID:18986645 PMID:23825647
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDlipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP2 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP2 mRNA]PMID:18986645
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNAPMID:33091441
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