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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2decreases expressionEXP 6480464CTDNicotine results in decreased expression of SOD2 proteinPMID:28681937
Sod2increases expressionEXP 6480464CTDNicotine results in increased expression of SOD2 proteinPMID:18343235
Sod2multiple interactionsEXP 6480464CTD[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD2 proteinPMID:29617909
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDNicotine results in decreased expression of SOD2 proteinPMID:22687363
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDresveratrol inhibits the reaction [Nicotine results in decreased expression of SOD2 protein]PMID:22687363
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTDSOD2 gene SNP affects the susceptibility to [Pesticides co-treated with Nicotine]PMID:29747151
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