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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3100
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp7
Name: matrix metallopeptidase 7
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp7affects response to substanceISOMMP7 (Homo sapiens)6480464CTDMMP7 promoter SNP affects the susceptibility to NicotinePMID:25847246
Mmp7increases expressionISOMMP7 (Homo sapiens)6480464CTDNicotine results in increased expression of MMP7 mRNA; Nicotine results in increased expression of MMP7 proteinPMID:20061081 PMID:25847246
Mmp7multiple interactionsISOMmp7 (Mus musculus)6480464CTD[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]PMID:20230807
Mmp7multiple interactionsISOMMP7 (Homo sapiens)6480464CTDCREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]; MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]; MMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]PMID:20061081 PMID:25847246
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