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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chat
Name: choline O-acetyltransferase
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chatdecreases activityEXP 6480464CTDNicotine results in decreased activity of CHAT proteinPMID:21633116
Chatincreases activityEXP 6480464CTDNicotine results in increased activity of CHAT proteinPMID:21633116 PMID:30247698
Chatmultiple interactionsEXP 6480464CTDNicotine inhibits the reaction [Vanadium results in decreased expression of CHAT protein]; Nicotine promotes the reaction [Bucladesine results in increased expression of CHAT protein]PMID:20361958 PMID:22119111
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