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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10730 Species: Mus musculus RGD Object: Gene Symbol: Hras1 Name: Harvey rat sarcoma virus oncogene 1

Acc ID: CHEBI:18422 Term: sulfur dioxide Definition: A sulfur oxide that has formula O2S. CasRN: 7446-09-5 Chemical ID: MESH:D013458

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:2827	6480464	CTD	[Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS mRNA [Sulfur Dioxide co-treated with Benzo(a)pyrene] results in increased expression of HRAS protein	PMID:19408242
multiple interactions	ISO	RGD:2827	6480464	CTD	Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS protein] Sulfur Dioxide promotes the reaction [Benzo(a)pyrene results in increased expression of HRAS mRNA]	PMID:20064080
increases expression	ISO	RGD:2827	6480464	CTD	Sulfur Dioxide results in increased expression of HRAS mRNA Sulfur Dioxide results in increased expression of HRAS protein	PMID:20064080 PMID:19408242
increases expression	ISO	RGD:2827	6480464	CTD	Sulfur Dioxide results in increased expression of HRAS protein Sulfur Dioxide results in increased expression of HRAS mRNA	PMID:19408242 PMID:20064080