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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2652 Species: Rattus norvegicus RGD Object: Gene Symbol: Gad1 Name: glutamate decarboxylase 1

Acc ID: CHEBI:18405 Term: pyridoxal 5'-phosphate Definition: The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal. CasRN: 54-47-7 Chemical ID: MESH:D011732

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects binding	ISO	RGD:730853	6480464	CTD	Pyridoxal Phosphate binds to GAD1 protein modified form	PMID:15686475
increases activity	ISO	RGD:10615	6480464	CTD	Pyridoxal Phosphate results in increased activity of GAD1 protein	PMID:171340
decreases activity	EXP		6480464	CTD	Pyridoxal Phosphate results in decreased activity of GAD1 protein	PMID:7463050