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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:18358
Term: methoxsalen
Definition: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Chemical ID: MESH:D008730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2decreases expressionEXP 6480464CTDMethoxsalen results in decreased expression of NR0B2 mRNAPMID:28552422
Nr0b2increases expressionISONR0B2 (Homo sapiens)6480464CTDMethoxsalen results in increased expression of NR0B2 proteinPMID:30419252
Nr0b2multiple interactionsISONR0B2 (Homo sapiens)6480464CTDVDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]PMID:30419252
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