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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2096
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
Acc ID: CHEBI:18295
Term: histamine
Definition: A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID: MESH:D006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alox5multiple interactionsISOALOX5 (Homo sapiens)6480464CTDALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]PMID:9609743
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