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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11046 Species: Mus musculus RGD Object: Gene Symbol: P4hb Name: prolyl 4-hydroxylase, beta polypeptide

Acc ID: CHEBI:18258 Term: 3,3',5-triiodo-L-thyronine Definition: An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. CasRN: 6893-02-3 Chemical ID: MESH:D014284

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:3244	6480464	CTD	P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein] P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH mRNA] bisphenol A inhibits the reaction [Triiodothyronine binds to P4HB protein]	PMID:17928132
affects binding	ISO	RGD:3244	6480464	CTD	Triiodothyronine binds to P4HB protein	PMID:17928132
multiple interactions	ISO	RGD:3244	6480464	CTD	P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA] P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]	PMID:22201216
multiple interactions	ISO	RGD:3244	6480464	CTD	4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine binds to P4HB protein] Polychlorinated Biphenyls metabolite inhibits the reaction [Triiodothyronine binds to P4HB protein]	PMID:19374345
affects binding	ISO	RGD:3244	6480464	CTD	Triiodothyronine binds to P4HB protein	PMID:19374345 PMID:17928132
affects binding	ISO	RGD:3244	6480464	CTD	Triiodothyronine binds to P4HB protein	PMID:17928132 PMID:19374345