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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729 Species: Rattus norvegicus RGD Object: Gene Symbol: Snca Name: synuclein, alpha (non A4 component of amyloid precursor)

Acc ID: CHEBI:18243 Term: dopamine Definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. CasRN: 51-61-6 Chemical ID: MESH:D004298

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases response to substance	ISO	RGD:733186	6480464	CTD	SNCA gene mutant form results in increased susceptibility to Dopamine	PMID:15234109
affects abundance	ISO	RGD:733186	6480464	CTD	SNCA protein affects the abundance of Dopamine	PMID:17131421
affects response to substance	ISO	RGD:735748	6480464	CTD	SNCA affects the susceptibility to Dopamine	PMID:19409267
decreases abundance	ISO	RGD:735748	6480464	CTD	SNCA protein mutant form results in decreased abundance of Dopamine	PMID:18622040