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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:18009 Term: NADP(+) Definition: A NAD(P)(+) that has formula C21H29N7O17P3. CasRN: 53-59-8 Chemical ID: MESH:D009249

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:708379	6480464	CTD	[CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine	PMID:20825217
multiple interactions	EXP		6480464	CTD	[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein]	PMID:19818743
multiple interactions	EXP		6480464	CTD	[CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine	PMID:20825217
multiple interactions	EXP		6480464	CTD	[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene	PMID:21766881
multiple interactions	EXP		6480464	CTD	[CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine] [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CYB5A protein promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 7-hydroxyellipticine [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 9-hydroxyellipticine [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine	PMID:22390216