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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp2e1 Name: cytochrome P450, family 2, subfamily e, polypeptide 1

Acc ID: CHEBI:17967 Term: urethane Definition: A carbamate ester that has formula C3H7NO2. CasRN: 51-79-6 Chemical ID: MESH:D014520

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10451	6480464	CTD	1-aminobenzotriazole inhibits the reaction [CYP2E1 protein affects the metabolism of Urethane]	PMID:12704224
multiple interactions	ISO	RGD:10451	6480464	CTD	CYP2E1 gene mutant form inhibits the reaction [Urethane affects the expression of MKI67 protein]	PMID:15790490
decreases metabolic processing	ISO	RGD:10451	6480464	CTD	CYP2E1 gene mutant form results in decreased metabolism of Urethane	PMID:12704224
decreases response to substance	ISO	RGD:10451	6480464	CTD	CYP2E1 gene mutant form results in decreased susceptibility to Urethane	PMID:17093202
affects hydroxylation	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the hydroxylation of Urethane	PMID:15879495
affects metabolic processing	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the metabolism of Urethane	PMID:12704224 PMID:17979661 PMID:15879495
affects oxidation	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the oxidation of Urethane	PMID:20205516
increases response to substance	ISO	RGD:10451	6480464	CTD	CYP2E1 protein results in increased susceptibility to Urethane	PMID:15790490
multiple interactions	ISO	RGD:10451	6480464	CTD	[Urethane co-treated with Ethanol] results in increased activity of CYP2E1 protein	PMID:15582191
affects metabolic processing	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the metabolism of Urethane	PMID:17979661 PMID:12704224 PMID:15879495
affects metabolic processing	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the metabolism of Urethane	PMID:15879495 PMID:17979661 PMID:12704224
affects metabolic processing	ISO	RGD:10451	6480464	CTD	CYP2E1 protein affects the metabolism of Urethane	PMID:12704224 PMID:15879495 PMID:17979661