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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621808 Species: Rattus norvegicus RGD Object: Gene Symbol: Park7 Name: parkinson protein 7

Acc ID: CHEBI:17963 Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Definition: A phenylpyridine that has formula C12H15N. CasRN: 28289-54-5 Chemical ID: MESH:D015632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases response to substance	ISO	RGD:1552781	6480464	CTD	PARK7 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	PMID:15784737
increases expression	ISO	RGD:1552781	6480464	CTD	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA	PMID:20230807
multiple interactions	ISO	RGD:1552781	6480464	CTD	Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PARK7 mRNA] [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PARK7 mRNA	PMID:20230807