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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases response to substanceEXP 6480464CTDHMOX1 protein results in decreased susceptibility to GentamicinsPMID:18842672
Hmox1increases expressionEXP 6480464CTDGentamicins results in increased expression of HMOX1 mRNAPMID:18172885 PMID:18289764 PMID:20118187 PMID:22061828 PMID:33387578
Hmox1multiple interactionsEXP 6480464CTDHMOX1 protein promotes the reaction [Gentamicins results in increased expression of BCL2L1 protein]PMID:18842672
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDGentamicins results in increased expression of HMOX1 mRNA; Gentamicins results in increased expression of HMOX1 proteinPMID:26260164
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDHMOX1 protein inhibits the reaction [Gentamicins results in increased abundance of Reactive Oxygen Species]; HMOX1 protein inhibits the reaction [Gentamicins results in increased cleavage of and results in increased activity of CASP3 protein]; HMOX1 protein inhibits the reaction [Gentamicins results in increased localization of RELA protein]; HMOX1 protein promotes the reaction [Gentamicins results in increased expression of HAX1 protein]PMID:18842672
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